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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| NTR0024-2 | 7 days | 2 µg | $120.00 |
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| NTR0024-10 | 7 days | 10 µg | $290.00 | |||
| NTR0024-1 | 7 days | 1 mg | $7,488.00 |
Product Overview | |
| Name | GDNF Mouse |
|---|---|
| Description | |
| Glial-Derived Neurotrophic Factor Mouse Recombinant | |
| Accession (Primary) | P48540 |
| Synonyms | |
| ATF1, ATF2, HFB1-GDNF, GDNF. | |
| Introduction | |
| GDNF promotes the survival and differentiation of neurons in culture, and is able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease. GDNF enhances survival and morphological differentiation of neurons and increases their high-affinity uptake. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| GDNF was lyophilized from a sterile solution containing 1xPBS, pH 7.4. | |
| Stability | |
| Lyophilized Glial-derived Neurotrophic Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GDNF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 98.0% as determined by HPLC analysis and by SDS-PAGE. | |
| Amino acid sequence | |
| SPDKQAALP RRENRNRQAAA ASPENSRGKG RRGQRGKNRG CVLTAIHLNV TDLGLGYETK EELIFRYCSG SCESAETMYD KILKNLSRSR RLTSDKVGQA CCRPVAFDDD LSFLDDNLVY HILRKHSAKR CGCI | |
| Biological Activity | |
| Recombinant rat GDNF has full biological activity when compared to standards. The ED50, determined by a cell proliferation assay using rat C6 cells, is less than 0.2ng/ml corresponding to a specific activity of more than 5,000,000IU/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Glial Derived Neurotrophic Factor in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| GDNF Mouse is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P48540 ) | |
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ADMEbio Team
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