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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| NTR0036-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| NTR0036-20 | 7 days | 20 µg | $290.00 | |||
| NTR0036-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | MANF Human, His |
|---|---|
| Description | |
| Mesencephalic Astrocyte-Derived Neurotrophic Factor Human Recombinant, His Tag | |
| Accession (Primary) | P55145 |
| Synonyms | |
| Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET, Manf, Armet. | |
| Introduction | |
| MANF is a 20kDa protein which belongs to the ARMET family. MANF was originally known as an arginine-rich region protein which was extremely mutated in a large number of tumors. MANF Expression is induced during ER stress, signifying that MANF takes part in protein quality control during ER stress. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4. | |
| Stability | |
| Lyophilized MANF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MANF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIEEELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDNQ IDLSTVDLKK LRVKELKKIL DDWGEMCKGC AEKSDYIRKI NELMPKYAPK AASARTDL. | |
| Biological Activity | |
| The ED 50 as determined by a cell proliferation assay using rat C6 cells is less than 10 µg/ml, corresponding to a specific activity of >100 IU/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized MANF in sterile 18M-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| MANF Human, His is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P55145 ) | |
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ADMEbio Team
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