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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| NTR0067-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| NTR0067-20 | 7 days | 20 µg | $290.00 | |||
| NTR0067-1 | 7 days | 1 mg | $5,616.00 |
Product Overview | |
| Name | PEDF Human |
|---|---|
| Description | |
| Pigment Epithelium-Derived Factor Human Recombinant | |
| Accession (Primary) | P36955 |
| Synonyms | |
| Pigment epithelium-derived factor, PEDF, Serpin-F1, SerpinF1, EPC-1, EPC1, PIG35. | |
| Introduction | |
| PEDF is a neurotrophic protein that induces extensive neuronal differentiation in retinoblastoma cells. SerpinF1 is a potent inhibitor of angiogenesis. EPC1 doesn’t undergo the stressed to relaxed conformation transition characteristic as of the active serpins since it exhibits no serine protease inhibitory activity. Aqueous humour level of asymmetric dimethylarginine is correlated with PEDF in humans. ADMA and PEDF levels are increased in response to inflammation in uveitis. Lack of PEDF expression is a potent factor for the enhancement of tumor growth and angiogenesis in breast cancer. PEDF & VEGF genes contribute to the development of diabetic retinopathy. PEDF and VEGF structural changes in blood vessel wall play an important role in the pathophysiology of PD patients. PEDF-overexpressing tumors exhibited reduced intratumoral angiogenesis. SerpinF1 is a new promising approach for the treatment of osteosarcoma. Levels of the natural ocular anti-angiogenic factor SentrinF1 (PEDF) is associated with proliferative retinopathy. VEGF secreted by retinal pigment epithelial cells upregulates PEDF expression via VEGFR-1 in an autocrine manner. Sentrin-F1 concentration in the aqueous humor of diabetic patients predicts who will develop progression of retinopathy. PEDF blocks angiogenic effects of leptin through its anti-oxidative properties. | |
| Source | |
| HEK 293. | |
| Physical Appearance | |
| Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The filtered (0.4 µm) concentrated (0.5mg/ml) protein solution was lyophilized with 20mM Tris & 20mM NaCl pH-7.5. | |
| Stability | |
| Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time. | |
| Purity | |
| Greater than 95% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| QNPASPPEEG SPDPDSTGAL VEEEDPFFKV PVNKLAAAVS NFGYDLYRVR SSTSPTTNVL LSPLSVATAL SALSLGAEQR TESIIHRALY YDLISSPDIH GTYKELLDTV TAPQKNLKSA SRIVFEKKLR IKSSFVAPLE KSYGTRPRVL TGNPRLDLQE INNWVQAQMK GKLARSTKEI PDEISILLLG VAHFKGQWVT KFDSRKTSLE DFYLDEERTV RVPMMSDPKA VLRYGLDSDL SCKIAQLPLT GSMSIIFFLP LKVTQNLTLI EESLTSEFIH DIDRELKTVQ AVLTVPKLKL SYEGEVTKSL QEMKLQSLFD SPDFSKITGK PIKLTQVEHR AGFEWNEDGA GTTPSPGLQP AHLTFPLDYH LNQPFIFVLR DTDTGALLFI GKILDPRGP A AADYKDDDDK . | |
| Solubility | |
| It is recomnded to add deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. | |
| Precautions | |
| PEDF Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P36955 ) | |
Background |
About PEDF Human Also known as “Pigment Epithelium-Derived Factor” or “SERPINF1,” PEDF is a multifunctional protein found in vertebrates. It has anti-tumorigenic, anti-angiogenic, and neurotrophic functions. Currently, it’s being researched as a candidate for treatment for several conditions, including heart disease and cancer. What’s the Function of PEDF Human Recombinant? PEDF is created/secreted in several tissues across the body. It has a unique anti-angiogenic action because of its induction of apoptosis in proliferating endothelial cells. Also, PEDF can inhibit many angiogenic factors, including VEGF and FGF-2. PEDF-R is currently the only known signaling receptor to be used by a serpin family member. What’s the Application of PEDF Human Recombinant? This version of PEDF is produced in E. Coli. It’s a single, non-glycosylated, polypeptide chain that contains 400 amino acids. It has a molecular mass of 44.5 kDa, and it’s purified by proprietary chromatographic techniques. The main purpose of PEDF human recombinant is for research. It has the potential to become a potential treatment for different angiogenesis-related diseases, including various cancers. Moreover, it can become crucial during the recovery from vasculature- related neurodegenerative illness. Such a discovery could be revolutionary for the world, which is why more research is needed to determine the effect of this non-inhibitory serpin on the body. |
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ADMEbio Team
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