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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| ABZ1920-100 | 2 weeks | 100 µL | $499.00 |
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| ABZ1920-20 | 2 weeks | 20 µL | $149.00 |
Product Overview | |
| Name | Pellino 1 Rabbit mAb |
|---|---|
| Accession (Primary) | Q96FA3 |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Isotype | IgG |
| Species Reactivity | |
| Reacts With | Human, Mouse, Rat |
| Calculated MW | |
| Calculated MW: 46 kDa; Observed MW: 46 kDa | |
| Buffer System | |
| Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. | |
| Recommended Dilution | |
| WB-1:500-1:1000; IP-1:20; IF-1:50-1:200 | |
| Purification | |
| Affinity Purified | |
| Conjugation | |
| Unconjugated | |
| Modification | |
| Unmodified | |
| Form | |
| Liquid | |
| Background | |
| E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609). | |
Target Information: ( Q96FA3 ) | |
| Name | PELI1 |
| Gene ID | 57162 |
| Other Names | |
| Pellino-related intracellular-signaling molecule; RING-type E3 ubiquitin transferase pellino homolog 1 | |
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ADMEbio Team
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ADMEbio Team
