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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0053-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| RCP0053-20 | 7 days | 20 µg | $290.00 | |||
| RCP0053-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | ANG Human |
|---|---|
| Description | |
| Angiogenin Human Recombinant | |
| Accession (Primary) | P03950 |
| Synonyms | |
| Angiostatin, Angiostatin Kringles 1-3, Ang K1-3. | |
| Introduction | |
| Ang K1-3 is a proteolytic fragment of plasminogen containing the first three kringle structures. A specific inhibitor of endothelial cell growth and angiogenesis. More active relative to kringles 1-4. Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth. | |
| Source | |
| Escherichia coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Lyophilized from a 0.2 µm filtered concentrated (1.0mg/ml) solution in 20mM NaAc, pH5.5, 4% mannitol. | |
| Stability | |
| The lyophilized Angiostatin K1-3 is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| VYLSECKTGN GKNYRGTMSK TKNGITCQKW SSTSPHRPRF SPATHPSEGL EENYCRNPDN DPQGPWCYTT DPEKRYDYCD ILECEEECMH CSGENYDGKI SKTMSGLECQ AWDSQSPHAH GYIPSKFPNK NLKKNYCRNP DRELRPWCFT TDPNKRWELC DIPRCTTPPP SSGPTYQCLKGTGENYRGNV AVTVSGHTCQ HWSAQTPHTH NRTPENFPCK NLDENYCRNP DGKRAPWCHT TNSQVRWEYC KIPSCDSSP. | |
| Biological Activity | |
| The activity is assayed on anti-proliferation and anti-migration of endothelial cells in vitro and anti-angiogenesis in vivo. The specific activity of anti-migration of endothelial cells in vitro is 55,000 Units/mg. | |
| Solubility | |
| We recommend to briefly centrifuge the vial prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions. | |
| References | |
| Title: Regenerative protein thymosin b-4 is a novel regulator of purinergic signaling. Publication: Published online before printNovember 24, 2010, doi: 10.1096/fj.10-169417 March 2011 The FASEB Journal vol. 25no. 3907-915. Link: http://www.fasebj.org/content/25/3/907.full.pdf+html | |
| Precautions | |
| ANG Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P03950 ) | |
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ADMEbio Team
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