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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0176-2 | 7 days | 2 µg | $120.00 |
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| RCP0176-10 | 7 days | 10 µg | $290.00 | |||
| RCP0176-1 | 7 days | 1 mg | $7,680.00 |
Product Overview | |
| Name | Bax Mouse |
|---|---|
| Description | |
| Bax Mouse Recombinant | |
| Accession (Primary) | Q07813 |
| Synonyms | |
| Apoptosis regulator BAX membrane isoform alpha, Bax, Bcl2-associated X protein. | |
| Introduction | |
| Bcl-2–associated X protein (Bax) belongs to the Bcl-2 protein family. Bax is a pro-apoptotic Bcl-2 protein containing BH1, BH2 and BH3 domains. Bax accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor bcl2 or its adenovirus homolog e1b 19k protein. Bax induces the release of cytochrome c, activation of casp3, and thereby apoptosis. Bax is expressed in a wide variety of tissues, with highest levels in the testis and ovary. Tumor suppressor protein p53 upregulates the expression of BAX. Bax has been shown to be involved in p53-mediated apoptosis. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| The 1mg/ml protein contains 10mM Tris-HCl pH-8, 1mM EDTA and 150mM NaCl, 10% glycerol, 0.1% tween & 10mM glutathione. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Precautions | |
| Bax Mouse is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q07813 ) | |
References |
1. Title :Bax Regulates Production of Superoxide in Both Apoptotic and Nonapoptotic Neurons: Role of Caspases. Publication : The Journal of Neuroscience, 1 December 2010, 30(48): 16114-16127; doi: 10.1523/?JNEUROSCI.2862-10.2010 The Journal of Neuroscience, 1 December 2010, 30(48): 16114-16127; doi: 10.1523/?JNEUROSCI.2862-10.2010 Link : Bax prospec publication 2. Title :Interaction of IGF-binding Protein-3 and BAX in Mitochondria Promotes Male Germ Cell Apoptosis Publication :First Published on November 3, 2009, doi: 10.1074/jbc.M109.046847 January 15, 2010 The Journal of Biological Chemistry, 285, 1726-1732. Link : Bax Mouse prospec publication |
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ADMEbio Team
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