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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0186-2 | 7 days | 2 µg | $120.00 |
Select product before adding to cart
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| RCP0186-10 | 7 days | 10 µg | $290.00 | |||
| RCP0186-1 | 7 days | 1 mg | $7,680.00 |
Product Overview | |
| Name | Bcl 2 Human (minus NWGR domain) |
|---|---|
| Description | |
| B-Cell Leukemia/Lymphoma 2 Human Recombinant (–NWGR) | |
| Accession (Primary) | P10415 |
| Synonyms | |
| BclXL, Bcl-X(L), Bcl-XL. | |
| Introduction | |
| Bcl-XL is a transmembrane protein located in the mitochondrial membranes of cells that are long-lived and postmitotic, such as adult brain cells. It plays arole in the signal transduction pathway of the FAS-Ligand. Bcl-XL is an anti-apoptotic protein which is a member of the Bcl-2 family which are able to form heterodimers, and this is an significant event in the regulation of apoptosis. BCL-XL is involved in the survival of cancer cells. Bcl-xL is the leading monitor of apoptosis/active cell suicide. Bcl-xL has cell death repressor activity and therefore acts as a survival protein. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The protein contains 10mM Tris-HCl pH-8, 1mM EDTA and 250mM NaCl. | |
| Stability | |
| Lyophilized Bcl-XL although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Bcl-XL should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Solubility | |
| Suspend BclXL in 1000 µl sterile 18M-cm H2O, over night at 4°C. Dilute 10 fold into selected buffer system.Bcl-XL has tendency to form intramolecular disulfide bond, 5mM DTT is recommended in assay buffer. When running SDS-PAGE gel, 10mM DTT is recommended. | |
| Precautions | |
| Bcl 2 Human (minus NWGR domain) is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P10415 ) | |
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ADMEbio Team
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ADMEbio Team
