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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0203-5 | 7 days | 5 µg | $120.00 |
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| RCP0203-20 | 7 days | 20 µg | $290.00 | |||
| RCP0203-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | BEND6 Human |
|---|---|
| Description | |
| BEN Domain Containing 6 Human Recombinant | |
| Accession (Primary) | Q5SZJ8 |
| Introduction | |
| Serratia marcescens secretes an endonuclease that has exceptionally high specific activity to the medium that surrounds it. The Benzonase Nuclease is mainly used for elimination of nucleic acid contamination from purified proteins, downstream processing, reduction of viscosity etc. Nucleic acid contaminants are caused by nuclease released to the medium. The DNA is being destroyed by the release of the S. marcescens nuclease and it acts as the killer gene for the auto destruction of microorganisms. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| The Benzonase Nuclease solution contains 50% glycerol, 50 mM Tris-HCl pH 8.0, 20 mM NaCl and 2 mM MgCl2. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 9 0% as determined by SDS-PAGE. | |
| Unit Definition | |
| 1U Benzonase Nuclease is defined as the amount of enzyme that causes a ΔA 260 of 1 in 30 min, which corresponds to complete digestion of 37 µg DNA. Standard reaction conditions are 1mg/ml sonicated DNA substrate in 50mM Tris-HCl pH 8.0, 0.1mg/ml BSA, 1mM MgCl 2 , incubated at 37°C. | |
| Specificity | |
| Unspecific (DNA, RNA) attacks all nucleic acids (single strand, double strand, circular, supercoiled) with no apparent sequence preference. Final reaction product: 5’-mono-phosphate terminated oligonucleotides (3-5 bases). Protease Activity: Not detectable | |
| Precautions | |
| BEND6 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q5SZJ8 ) | |
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