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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0214-2 | 7 days | 2 µg | $120.00 |
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| RCP0214-10 | 7 days | 10 µg | $290.00 | |||
| RCP0214-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | BID Human |
|---|---|
| Description | |
| BH3 Interacting Domain Death Agonist Human Recombinant | |
| Accession (Primary) | P55957 |
| Synonyms | |
| BH3-interacting domain death agonist, p22 BID, BID, FP497, MGC15319, MGC42355. | |
| Introduction | |
| BID is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling, BID interacts with another Bcl-2 family of cell death regulators, called Bax, they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1, Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered colorless liquid formulation. | |
| Formulation | |
| The Mouse BID protein solution contains 10mM Tris-HCl pH-8, 1mM EDTA and 250mM NaCl. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Precautions | |
| BID Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P55957 ) | |
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ADMEbio Team
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