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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0285-5 | 7 days | 5 µg | $770.00 |
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| RCP0285-25 | 7 days | 25 µg | $2,090.00 | |||
| RCP0285-50 | 7 days | 50 µg | $2,640.00 |
Product Overview | |
| Name | C3b Inactivated Mouse |
|---|---|
| Description | |
| Complement C3b Inactivated Mouse | |
| Synonyms | |
| Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3, CPAMD1. | |
| Introduction | |
| C3b is derived from native C3 upon cleavage with the alternative pathway C3 convertase and release of C3a. C3b is essential to the function of all 3complement pathways. Initiation of each pathway generates proteolytic enzyme complexes (C3 convertases) which binds the target surface. These enzymes cleave a peptide bond in C3 releasing the anaphylatoxin C3a and activating C3b. Most of the C3b created during complement activation. Surface-bound C3b is needed in all 3 pathways for effective activation of C5 and formation of C5b-9 complexes which lyse the target cell membrane. Surface-bound C3b and its breakdown products iC3b and C3d are identifyid by various receptors on lymphoid and phagocytic cells which use the C3b ligand to stimulate antigen presentation to cells of the adaptive immune system. It results in an expansion of target-specific B-cell and T-cell populations. | |
| Source | |
| Mouse Plasma. | |
| Physical Appearance | |
| Sterile filtered solution. | |
| Formulation | |
| C3b solution contains Phosphate buffered saline, pH 7.2 . | |
| Stability | |
| C3b Mouse is stable at 4°C if entire vial will be used within 2-4 weeks. Store, frozen below -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Precautions | |
| C3b Inactivated Mouse is for research use only and not for use in diagnostic or therapeutic procedures. | |
Background |
Complement component 3b (C3b) is a key protein in the complement system, a crucial component of the innate immune response. C3b plays a pivotal role in opsonization, inflammation, and clearance of pathogens and damaged cells. In mouse models, research on C3b has provided valuable insights into its mechanism of action, activity, and implications in immune function. This paper aims to delve into the dynamics of mouse C3b, shedding light on its functional attributes and potential applications in immunological research. C3b Inactivated protein has lost its biological capabilities due to structural changes compared to C3b that has binding sites to factor P, factor H, factor B, factorC5, and factor-I and therefore it destroys these sites. Significantly, C3b inactivated protein cannot bind factor B and is therefore it cannot participate in complement activation. C3b inactivated protein still binds tC50 properdin and CR3 receptor. |
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ADMEbio Team
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