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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0287-5 | 7 days | 5 µg | $770.00 |
Select product before adding to cart
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| RCP0287-25 | 7 days | 25 µg | $2,090.00 | |||
| RCP0287-50 | 7 days | 50 µg | $2,640.00 |
Product Overview | |
| Name | C3b Rabbit |
|---|---|
| Description | |
| Complement C3b Rabbit | |
| Synonyms | |
| Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3, CPAMD1. | |
| Introduction | |
| C3b is derived from native C3 upon cleavage with the alternative pathway C3 convertase and release of C3a. C3b is essential to the function of all 3complement pathways. Initiation of each pathway generates proteolytic enzyme complexes (C3 convertases) which binds the target surface. These enzymes cleave a peptide bond in C3 releasing the anaphylatoxin C3a and activating C3b. Most of the C3b created during complement activation. Surface-bound C3b is needed in all 3 pathways for effective activation of C5 and formation of C5b-9 complexes which lyse the target cell membrane. Surface-bound C3b and its breakdown products iC3b and C3d are identifyid by various receptors on lymphoid and phagocytic cells which use the C3b ligand to stimulate antigen presentation to cells of the adaptive immune system. It results in an expansion of target-specific B-cell and T-cell populations. | |
| Source | |
| Rat Plasma. | |
| Physical Appearance | |
| Sterile filtered solution. | |
| Formulation | |
| C3b solution contains contains phosphate Buffered Saline , pH 7. 2 . | |
| Stability | |
| C3b Rat is stable at 4°C if entire vial will be used within 2-4 weeks. Store, frozen below -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Precautions | |
| C3b Rabbit is for research use only and not for use in diagnostic or therapeutic procedures. | |
Background |
Rabbit C3b serves as a critical opsonin, enhancing the recognition and engulfment of pathogens and immune complexes by phagocytic cells. Through its covalent attachment to target surfaces, C3b facilitates the recognition of foreign antigens and promotes their clearance by the immune system. C3b contributes to the inflammatory response by generating C5 convertase complexes, leading to the cleavage of C5 into C5a and C5b. C5a is a potent chemoattractant and activator of immune cells, promoting the recruitment of neutrophils and macrophages to sites of infection or tissue damage. |
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ADMEbio Team
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ADMEbio Team
