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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0293-20 | 7 days | 20 µg | $440.00 |
Select product before adding to cart
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| RCP0293-100 | 7 days | 100 µg | $1,320.00 | |||
| RCP0293-1 | 7 days | 1 mg | $5,600.00 |
Product Overview | |
| Name | C4b Human |
|---|---|
| Description | |
| Complement C4b Human | |
| Accession (Primary) | P0C0L5 |
| Synonyms | |
| C4bp, C4BP, C4b-binding protein alpha chain, Proline-rich protein, PRP, C4BPA | |
| Introduction | |
| C4BP has a flower shaped structure with each alpha chain radiating out from a central core. The arms are linked by disulfide bonds in the centre and the ends of each arm bind C4b. C4BP acts as a cofactor allowing factor I to split and permanently inactivate C4b. C4b binding protein modulates complement activation of the classical and lectin pathways. C4BP binds to C4b and accelerates the dissociation of C2a from the C3/C5 convertase C4b,C2a. This inactivates the central enzyme of both pathways. Studies have shown that on surfaces densely coated with C4b, C4BP can bind up to four C4b molecules simultaneously. | |
| Source | |
| Human Plasma. | |
| Physical Appearance | |
| Sterile filtered solution. | |
| Formulation | |
| C4BP solution (1mg/ml) contains PBS, pH 7.2. | |
| Stability | |
| C4BP Human is stable at 4°C if entire vial will be used within 2-4 weeks. Store, frozen below -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 90% as determined by SDS-PAGE. | |
| Human Virus Test | |
| Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV, HTLV-I &II, STS and HBSAG. | |
| Precautions | |
| C4b Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P0C0L5 ) | |
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ADMEbio Team
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ADMEbio Team
