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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0302-5 | 7 days | 5 µg | $120.00 |
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| RCP0302-25 | 7 days | 25 µg | $290.00 | |||
| RCP0302-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | C6ORF108 Human |
|---|---|
| Description | |
| Chromosome 6 Open Reading Frame 108 Human Recombinant | |
| Accession (Primary) | O43598 |
| Synonyms | |
| Complement component C7, C7. | |
| Introduction | |
| C7 is necessary for formation of the membrane attack complex and is activated by bindingat the cell membrane to recently-formed C5b,C6 complexes. Each pathway of complement activation generates proteolytic enzyme complexes which bind the target surface. These enzymes cleave a peptide bond in the larger alpha chain of C5 releasing C5a and activating C5b. Although C5b is unstable it remains bound to the activating complex for a few minutes during which it binds a single C6 from the surrounding fluid or it decays and is no longer capable of forming MAC. The C5b,6 complex may also remain connected to the C3/C5 convertase where the binding of a single C7 exposes a membrane-binding region and C5b,6,7 can enter into the bilipid layer of the target cell. | |
| Source | |
| Human Plasma. | |
| Physical Appearance | |
| Sterile filtered solution. | |
| Formulation | |
| C7 protein solution contains 10mM Sodium phosphate and 145mM NaCl, pH 7.3. | |
| Stability | |
| C7 Human is stable at 4°C if entire vial will be used within 2-4 weeks. Store, frozen below -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 90.0% as determined by SDS-PAGE. | |
| Human Virus Test | |
| Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV and HBSAG. | |
| Precautions | |
| C6ORF108 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( O43598 ) | |
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ADMEbio Team
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