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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0304-2 | 7 days | 2 µg | $120.00 |
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| RCP0304-10 | 7 days | 10 µg | $290.00 | |||
| RCP0304-100 | 7 days | 100 µg | $1,920.00 |
Product Overview | |
| Name | C7ORF49 Human |
|---|---|
| Description | |
| Chromosome 7 Open Reading Frame 49 Human Recombinant | |
| Accession (Primary) | Q9BWK5 |
| Introduction | |
| Native human C8 is a glycosylated protein consist of 3 polypeptide chains: The alpha chain and the gamma chain are disulfide linkedwhereas, The beta chain is non-covalently bound to the a-g complex. C8 is necessary for formation of the membrane attack complex and is activated by binding on the cell membrane newly-formed C5b,C6,C7 complexes. Each pathway of complement activation generates proteolytic enzyme complexes which bind the target surface. These enzymes cleave a peptide bond in the larger alpha chain of C5 releasing C5a and activating C5b. Although C5b is unstable it remains bound to the activating complex for a few minutes during which it binds a single C6 from the surrounding fluid or it decays and is no longer capable of forming MAC.The C5b,6 complex may also remain connected to the C3/C5 convertase where the binding of a single C7 exposes a membrane-binding region and C5b,6,7 can enter into the bilipid layer of the target cell. Each C5b-7 complex can bind 1 molecule of C8 causing the complex to enter more firmly into the membrane. | |
| Source | |
| Human Plasma. | |
| Physical Appearance | |
| Sterile filtered solution. | |
| Formulation | |
| C8 protein solution contains PBS pH 7.2. | |
| Stability | |
| C8 Human is stable at 4°C if entire vial will be used within 2-4 weeks. Store, frozen below -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 95% as determined by SDS-PAGE. | |
| Human Virus Test | |
| Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV and HBSAG. | |
| Precautions | |
| C7ORF49 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q9BWK5 ) | |
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ADMEbio Team
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ADMEbio Team
