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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0315-2 | 7 days | 2 µg | $120.00 |
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| RCP0315-10 | 7 days | 10 µg | $290.00 | |||
| RCP0315-100 | 7 days | 100 µg | $1,920.00 |
Product Overview | |
| Name | CADM1 Human |
|---|---|
| Description | |
| Cell Adhesion Molecule 1 Human Recombinant | |
| Accession (Primary) | Q9BY67 |
| Introduction | |
| Helicobacter pylori is a Gram negative bacteria which colonizes in the human stomach and stimulates gastric mucosal inflammations leading to acute gastritis-associated diseases among them are atrophic gastritis, peptic ulcer and gastric cancer. H. pylori is found in half of the world’s population and is defined as a group I carcinogens. . An important virulence factor of H. pylori is Cytotoxin-associated gene A (CagA) which is located at the end of an approximately 40-kb cluster of genes called cag pathoge¬nicity island (PAI). Cag PAI encodes a type-IV secretion system and transfers CagA protein into the intracellular region of gastric epithelial cell. This relocation induces cellular hyper proliferation, apoptosis and leading to failure of gastric epithelial cell in maintaining its normal cytoskeletal structure. Furthermore it increases the secretion of cytokines such as tumor necrosis factor (TNF) and interleukin (IL) 1, 6 and 8 by the epithelial cells. The IL-8 leads to extreme inflammatory responses and also stimulates the production of oxygen free radicals that could cause DNA damage to adjacent cells and lead to genetic modifications of gastric epithelial cells which are carcinogenic. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile filtered colorless solution. | |
| Formulation | |
| CagA Pylori recombinant protein is formulated in 1xPBS pH 7.4. | |
| Stability | |
| CagA Pylori although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles. | |
| Purity | |
| Greater than 95% pure as determined by 12% PAGE (Coomassie staining). | |
| Purification Method | |
| Purified by proprietary chromatographic technique. | |
| Precautions | |
| CADM1 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q9BY67 ) | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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ADMEbio Team
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ADMEbio Team
