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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0387-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| RCP0387-20 | 7 days | 20 µg | $290.00 | |||
| RCP0387-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | CEND1 Human |
|---|---|
| Description | |
| Cell Cycle Exit And Neuronal Differentiation 1 Human Recombinant | |
| Accession (Primary) | Q8N111 |
| Synonyms | |
| Histone H3-like centromeric protein A, Centromere protein A, CENP-A, Centromere autoantigen A, CENPA. | |
| Introduction | |
| Centromere proteins are a group of proteins which form and/or mediate the function of centromeres, the central structures of chromosomes to which spindle fibers/microtubuli attach and pull the chromosomes apart in cell division. Currently, 9 centromere proteins are known and designated CENPA to CENP-I. Most of the centromere proteins are targets of autoantibodies, the anti-centromere antibodies. CENPA is another important centromeric autoantigen in addition to CENPB: it has a molecular weight of approx. 20 kDa and is incorporated into centromeric chromatin due to its histone-like properties. CENPA antibodies are an important marker for correct diagnosis of Scleroderma / CREST syndrome in CENPB-autoantibody negative patients. | |
| Source | |
| Sf9 insect cells. | |
| Physical Appearance | |
| Sterile Filtered liquid formulation. | |
| Formulation | |
| CENPA is supplied in 20mM HEPES buffer pH-8, 100mM sodium chloride, and 6M Urea. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 90% as determined by SDS-PAGE. | |
| Applications | |
| Western-Blot with monoclonal anti-hexa-His-tag antibody & Scleroderma patient sera. | |
| Immunological functions | |
| 1. Binds IgG-type human auto-antibodies. 2. Standard ELISA test (checker-board analysis of positive/negative sera panels including CDC international reference sera). | |
| Coating concentration | |
| 0.15-0.4 µg/ml (depending on the type of ELISA plate and coating buffer). Suitable for biotinylation and iodination. | |
| Precautions | |
| CEND1 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q8N111 ) | |
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ADMEbio Team
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