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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0442-50 | 7 days | 50 µg | $400.00 |
Select product before adding to cart
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| RCP0442-100 | 7 days | 100 µg | $600.00 | |||
| RCP0442-1 | 7 days | 1 mg | $2,400.00 |
Product Overview | |
| Name | CITED2 (1-160) Human |
|---|---|
| Description | |
| Cbp/p300-Interacting Transactivator 2 (1-160) Human Recombinant | |
| Accession (Primary) | Q99967 |
| Synonyms | |
| MRG1, P35SRJ, CIT-ED2, Cbp/p300-interacting transactivator 2, MSG-related protein 1, MRG-1, CITED2. | |
| Introduction | |
| CITED2 is a significant transcriptional cofactor that takes part in multiple organ development. CITED2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a negative regulator for HIF1A through its competitive binding with HIF1A to CBP/p300. CITED2 is essential for mouse fetal liver hematopoiesis and is necessary for the appropriate formation of the hyaloid vasculature and for lens morphogenesis. CITED2 is a coactivator of HNF4alpha and necessary for liver development. CITED2 is a coactivator of PPAR-alpha and both participate in signaling cascades of hypoxic response and angiogenesis. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| The CITED2 solution contains 20mM Tris pH-8, 1mM DTT ,0.1M NaCl & 50% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 90.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA LMGEHIHYGA GNMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMGPPVASQGGSL PASMQLQKLN NQYFNHHPYP HNHYMPDLHP AAGHQMNGTN QHFRDCNPKH SGGSSTPGGS GGSSTPGGSG SSSGGGAGSS NSGGGSGSGN MPASVAHVPA AMLPPNVIDT DFIDEEVLMS LVIEMGLDRI KELPELWLGQ NEFDFMTDFV CKQQPSRVSC LEHHHHHH . | |
| Precautions | |
| CITED2 (1-160) Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q99967 ) | |
Background |
CITED2 also known as Cbp/p300-Interacting Trans activator 2 is an important transcriptional cofactor which is involved in multiple organ development. CITED2 is part of the CITED family which take an important role in gene regulation & cellular signalling. CITED2 is a cAMP-responsive element-binding protein interacting transcriptional modulator and an anticipated negative regulator for Recombinant human CITED2 protein 1 hypoxia-inducible factor (HIF) -1alpha by competing on the binding with HIF-1alpha to CBP/p300. CITED2 is essential for Mouse Fetal liver haematopoiesis and also mandatory for the appropriate formation of the hyaloid vasculature and for lens morphogenesis as well. CITED2 is recognized for its relations with transcriptional coactivators, such as CBP and p300 and also takes part in various biological processes, together with cardiovascular development, metabolism, as well as response to hypoxia. Moreover, the most valuable form of CITED2 for learning its functional roles & potential applications in cancer research and regenerative medicine is the Recombinant one which is produced by molecular cloning and expression systems. |
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