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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0454-2 | 7 days | 2 µg | $120.00 |
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| RCP0454-10 | 7 days | 10 µg | $290.00 | |||
| RCP0454-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | CLEC5A Human |
|---|---|
| Description | |
| C-Type Lectin Domain Family 5, Member A Human Recombinant | |
| Accession (Primary) | Q9NY25 |
| Synonyms | |
| C-type lectin domain family 5 member A , CLECSF5, MDL-1, MDL1, C-type lectin superfamily member 5, Myeloid DAP12-associating lectin 1. | |
| Introduction | |
| C-type lectin domain family 5-member A isoform 1 (CLEC5A) is part of the CTL/CTLD superfamily which carry various functions, for instance cell-cell signaling, cell adhesion, glycoprotein turnover, in addition to their inflammation & immune response abilities. CLEC5A operates as a cell attachment receptor for all 4 serotypes of Dengue virus in addition to Japanese encephalitis virus. CLEC5A binds to the dengue virus and it triggers signaling through the phosphylation of TYROBP, as a result no viral entrance occurs, however this interaction does stimulate proinflammatory cytokine release. CLEC5A preforms as a positive regulator of osteoclastogenesis and also a main regulator of synovial injury & bone erosion for the period of autoimmune joint inflammation. | |
| Source | |
| Sf9, Baculovirus cells. | |
| Physical Appearance | |
| Sterile Filtered clear solution. | |
| Formulation | |
| CLEC5A protein solution (0.25mg/ml) contains 20% glycerol, 1mM DTT & Phosphate buffered saline (pH7.4). | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 90.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| ADL PQIFNKS NDGFTTTRSY GTVSQIFGSS SPSPNGFITT RSYGTVCPKD WEFYQARCFF LSTSESSWNE SRDFCKGKGS TLAIVNTPEK LKFLQDITDA EKYFIGLIYH REEKRWRWIN NSVFNGNVTN QNQNFNCATI GLTKTFDAAS CDISYRRICE KNAK HHHHHH | |
| Precautions | |
| CLEC5A Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q9NY25 ) | |
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ADMEbio Team
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ADMEbio Team
