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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0617-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| RCP0617-20 | 7 days | 20 µg | $290.00 | |||
| RCP0617-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | DCAF7 Human |
|---|---|
| Description | |
| DDB1 and CUL4 Associated Factor 7 Human Recombinant | |
| Accession (Primary) | P61962 |
| Synonyms | |
| Deoxycytidine kinase, DCK, MGC117410, MGC138632. | |
| Introduction | |
| DCK (Deoxycytidine kinase) is a key enzyme in the salvage of deoxyribonucleosides and in the activation of clinically relevant nucleoside analogues. DCK is responsible for the 5`-phosphorylation of purine and pyrimidine deoxynucleosides to the corresponding monophosphates using ATP or UTP as phosphate donors. Deficiency of the DCK enzyme activity is linked to resistance to antiviral and anticancer chemotherapeutic agents, whereas increased DCK enzyme activity is linked to increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| DCK is supplied as a sterile filtered clear solution. | |
| Formulation | |
| The DCK solution (0.5mg/ml) contains 20mM Tris-HCl Buffer (pH 7.5), 1mM DTT, 0.1mM PMSF, 2mM EDTA and 10% Glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 90.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGS MATP PKRSCPSFSA SSEGTRIKKI SIEGNIAAGK STFVNILKQL CEDWEVVPEP VARWCNVQST QDEFEELTMS QKNGGNVLQM MYEKPERWSF TFQTYACLSR IRAQLASLNG KLKDAEKPVL FFERSVYSDR YIFASNLYES ECMNETEWTI YQDWHDWMNN QFGQSLELDG IIYLQATPET CLHRIYLRGR NEEQGIPLEY LEKLHYKHES WLLHRTLKTN FDYLQEVPIL TLDVNEDFKD KYESLVEKVK EFLSTL. | |
| Precautions | |
| DCAF7 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P61962 ) | |
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