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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0642-2 | 7 days | 2 µg | $360.00 |
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| RCP0642-5 | 7 days | 5 µg | $600.00 | |||
| RCP0642-10 | 7 days | 10 µg | $768.00 |
Product Overview | |
| Name | DKK1 Human Sf9 |
|---|---|
| Description | |
| Dickkopf-Related Protein 1 Human Recombinant, Sf9 | |
| Accession (Primary) | O94907 |
| Synonyms | |
| Dkk-1, mDkk-1, Dkk1, Dickkopf-related protein 1, Dickkopf-1. | |
| Introduction | |
| Dickkopf-related protein 1 (DKK1) antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by creating a ternary complex with the transmembrane protein KREMEN which promotes internalization of LRP5/6. DKKs have a significant role in vertebrate development, where they locally inhibit Wnt controlled processes for instance antero-posterior axial patterning, limb development, somitogenesis and eye formation. Furthermore, Dkks are involved in bone formation and bone disease, cancer and Alzheimer disease in Adults. | |
| Source | |
| HEK293 Cells. | |
| Physical Appearance | |
| Sterile Filtered clear solution. | |
| Formulation | |
| The DKK1 solution (0.25mg/ml) contains 50mM MES buffer (pH 6.5) and 30% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 95% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| TLNSVLINSN AIKNLPPPLG GAGGQPGSAV SVAPGVLYEG GNKYQTLDNY QPYPCAEDEE CGSDEYCSSP SRGAAGVGGV QICLACRKRR KRCMRHAMCC PGNYCKNGIC MPSDHSHFPR GEIEESIIEN LGNDHNAAAG DGYPRRTTLT SKIYHTKGQE GSVCLRSSDC AAGLCCARHF WSKICKPVLK EGQVCTKHKR KGSHGLEIFQ RCYCGEGLAC RIQKDHHQAS NSSRLHTCQR H HHHHHH | |
| Precautions | |
| DKK1 Human Sf9 is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( O94907 ) | |
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ADMEbio Team
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ADMEbio Team
