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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0687-50 | 7 days | 50 µg | $400.00 |
Select product before adding to cart
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| RCP0687-100 | 7 days | 100 µg | $600.00 | |||
| RCP0687-1 | 7 days | 1 mg | $2,400.00 |
Product Overview | |
| Name | DTL Human |
|---|---|
| Description | |
| Denticleless E3 Ubiquitin Protein Ligase Human Recombinant | |
| Accession (Primary) | Q9NZJ0 |
| Synonyms | |
| Dysbindin, SDY, DBND, HPS7, My031, FLJ30031, MGC20210, DKFZp564K192, Dystrobrevin-binding protein 1, Hermansky-Pudlak syndrome 7 protein homolog, Hps7-like protein, DTNBP1. | |
| Introduction | |
| DTNBP1 is involved in organelle biogenesis connected with melanosomes, platelet dense granules, and lysosomes. An analogous protein in murine is a part of a protein complex called BLOC-1, and connects to alpha- and beta-dystrobrevins, which are factors of the dystrophin-associated protein complex (DPC). Mutations in DTNBP1 gene are associated with Hermansky-Pudlak syndrome type 7. DTNBP1 gene may also be associated with schizophrenia. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| The DTNBP1 solution contains 20mM Tris pH-8, 0.5mM DTT, 0.1M NaCl, and 20% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSH MLS AHWEKKKTSL VELQEQLQQL PALIADLESM TANLTHLEAS FEEVENNLLHLEDLCGQCEL ERCKHMQSQQ LENYKKNKRK ELETFKAELD AEHAQKVLEM EHTQQMKLKE RQKFFEEAFQ QDMEQYLSTG YLQIAERREP IGSMSSMEVN VDMLEQMDLM DISDQEALDV FLNSGGEENT VLSPALGPES STCQNEITLQ VPNPSELRAK PPSSSSTCTD SATRDISEGG ESPVVQSDEE EVQVDTALAT SHTDREATPD GGEDSDS. | |
| Precautions | |
| DTL Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q9NZJ0 ) | |
Background |
Denticleless E3 ubiquitin protein ligase (DTL) is part of the E3 ubiquitin ligase family, fundamental to the ubiquitin-proteasome system, which adjusts protein degradation and modification in cells. DTL also participates in numerous critical biological processes, which comprises cell cycle progression, DNA repair, as well as embryonic development. More than a few diseases have been linked with the dysregulation of DTL in particular Cancer, this highlights the importance of DTL as a potential therapeutic goal. DTL takes an important part in regulating the cell cycle, mainly the transition from the G1 phase to the S phase. The degradation of cell cycle regulators, such as cyclins, is also mediated by DTL in that way assuring appropriate cell division in addition to preventing uncontrolled proliferation. DTL is also part of the DNA damage response mechanisms. It ubiquitinates vital proteins which are involved in DNA repair pathways, thus influencing the cellular response to genotoxic stress and preserving genomic integrity. |
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