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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP0932-2 | 7 days | 2 µg | $120.00 |
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| RCP0932-10 | 7 days | 10 µg | $290.00 | |||
| RCP0932-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | GM2A Human |
|---|---|
| Description | |
| GM2 Ganglioside Activator Human Recombinant | |
| Accession (Primary) | P17900 |
| Synonyms | |
| CSF-2, MGI-1GM, GM-CSF, Pluripoietin-alpha, Molgramostin, Sargramostim. | |
| Introduction | |
| GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of GMCSF is found extracellularly as a homodimer. GMCSF has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The protein was lyophilized from a sterile (0.2 µm) filtered solution containing 10mM sodium phosphate, pH 7.5. | |
| Stability | |
| Lyophilized GMCSF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GMCSF should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MAPTRPPSPV TRPWQHVDAI KEALSLLNNS NDTAAVMNET VDVVCEMFDP QEPTCVQTRL NLYKQGLRGS LTRLKSPLTL LAKHYEQHCP LTEETSCETQ SITFKSFKDS LNKFLFTIPF DCWGPVKK. | |
| Biological Activity | |
| The ED 50 , as determined by TF-1 cell proliferation is 4.52ng/ml corresponding to a specific activity which is 2.2 x 10^5 units/mg. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized GMCSF in sterile 18MΩ-cm H 2 O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| GM2A Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P17900 ) | |
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ADMEbio Team
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