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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP1088-2 | 7 days | 2 µg | $120.00 |
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| RCP1088-10 | 7 days | 10 µg | $290.00 | |||
| RCP1088-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | HSPB7 Human |
|---|---|
| Description | |
| Heat Shock 27kDa Protein Family, Member 7 Human Recombinant | |
| Accession (Primary) | Q9UBY9 |
| Synonyms | |
| HSPB8, H11, HMN2, CMT2L, DHMN2, E2IG1, HMN2A, HSP22, Heat shock protein beta-8, Alpha-crystallin C chain, Small stress protein-like protein HSP22, E2-induced gene 1 protein, Protein kinase H11, CRYAC. | |
| Introduction | |
| HSPB8 displays temperature-dependent chaperone activity. HSPB8 acts as a mn(2+)-dependent serine-threonine- specific protein kinase. we are not convinced that this is its true role. Defects in HSPB8 are a cause of distal hereditary motor neuropathy type ii (DHMN2) also known as distal spinal muscular atrophy (DSMA) and spinal muscular atrophy of the charcot-marie-tooth type. it is an autosomal dominant disorder of lower motor neurons characterized by distal muscle weakness. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The HSPB8 protein was lyophilized from a concentrated (1mg/ml) solution containing 20mM Tris-acetate, pH-7.6, 10mM NaCl, 0.1mM EDTA, 0.1mM PMSF, 15mM b-ME. | |
| Stability | |
| Lyophilized HSPB8 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution HSPB8 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized HSPB8 in sterile 18M-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| References | |
| Title : Roles of ERK and NF-?B in Interleukin-8 Expression in Response to Heat Shock Protein 22 in Vascular Smooth Muscle Cells. Publication: Korean J Physiol Pharmacol. 2008 Aug;12(4):171-176. Link: HSPB8 prospec publication Applications: HSP22 induces IL-8 in VSMCs via ERK1/2. | |
| Immunological Activity | |
| Immunoreactivity is confirmed by reaction with monoclonal mouse antibodies against HSPB8. | |
| Precautions | |
| HSPB7 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q9UBY9 ) | |
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