Hello, Sign in
My Account
My Account
New customer? Start here
| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP1174-50 | 7 days | 50 µg | $400.00 |
Select product before adding to cart
|
||
| RCP1174-100 | 7 days | 100 µg | $600.00 | |||
| RCP1174-1 | 7 days | 1 mg | $2,400.00 |
Product Overview | |
| Name | KLF7 (80-230) Human |
|---|---|
| Description | |
| Kruppel-Like Factor 7 (80-230) Human Recombinant | |
| Accession (Primary) | O75840 |
| Immunogen | |
| Anti-human KLF7 mAb, clone PAT3G3A, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human KLF7 protein 1-302 amino acids purified from E. coli. | |
| Synonyms | |
| UKLF, Krueppel-like factor 7, Ubiquitous krueppel-like factor, KLF7. | |
| Introduction | |
| Kruppel-Like Factor 7 (KLF7) is a part of the Kruppel-like transcriptional regulator family whose members regulate cell proliferation, differentiation and survival and contain 3 C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. KLF7 contributes to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and also by deregulating adipocytokine secretion in adipocytes. | |
| Physical Appearance | |
| Sterile filtered colorless solution. | |
| Formulation | |
| 1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide. | |
| Applications | |
| The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000. | |
| Type | |
| Mouse Anti Human Monoclonal. | |
| Clone | |
| PAT3G3A. | |
| Ig Subclass | |
| Mouse IgG1 heavy chain and Kappa light chain. | |
| Purification Method | |
| KLF7 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography. | |
| Storage Procedures | |
| For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. | |
| Stability / Shelf Life | |
| 12 months at -20°C. 1 month at 4°C. | |
| Precautions | |
| KLF7 (80-230) Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( O75840 ) | |
Background |
Kruppel-Like Factor 7 (KLF7) which is a part of the KLF family, plays an important roles in many biological processes, including cellular proliferation, differentiation and apoptosis. KLF7 functions as a transcription factor, binding to specific DNA sequences to regulate gene expression. KLF7 takes part in the regulation of metabolic pathways, including glucose homeostasis. KLF7 modulates insulin sensitivity and plays a role in adipocyte differentiation. KLF7 contributes to the progression of type 2 diabetes by inhibiting hormone expression and secretion in pancreatic beta-cells and also by deregulating adipocytokine secretion in adipocytes. KLF7 is critical in the development and maturation of neurons. KLF7 promotes the differentiation of neural progenitor cells and influences axon growth and synaptic plasticity. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Thank you,
ADMEbio Team
ADMEbio welcomes feedback from our customers.
Thank you,
ADMEbio Team
