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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP1186-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| RCP1186-20 | 7 days | 20 µg | $290.00 | |||
| RCP1186-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | KLRK1 Human |
|---|---|
| Description | |
| Killer Cell lectin-Like Receptor Subfamily K, Member 1 Human Recombinant | |
| Accession (Primary) | P26718 |
| Synonyms | |
| KMT5A, PR-Set7, SET07, SET8, SETD8, H4-K20-HMTase KMT5A. | |
| Introduction | |
| Lysine Methyltransferase 5A (KMT5A) is an enzyme which catalyzes both histones and non-histone proteins. KMT5A contributes to the maintenance of proper higher-order structure of DNA during mitosis. KMT5A takes part in cell-cycle-dependent transcriptional silencing and mitotic regulation in metazoans. KMT5A plays a role as a barrier to prevent cellular senescence through chromatinmediated regulation of senescence-associated metabolic remodeling. KMT5A mediates monomethylation of p53/TP53 at 'Lys-382', which leads to repress p53/TP53-target genes. The loss of KMT5A simultaneously stimulate nucleolar function and retinoblastoma protein-mediated mitochondrial metabolism. | |
| Source | |
| Sf9, Baculovirus cells. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| KMT5A protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 5mM DTT, 0.2M NaCl, 1mM EDTA and 50% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 85.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| M KAELQSEER KRIDELIESG KEEGMKIDLI DGKGRGVIAT KQFSRGDFVV EYHGDLIEIT DAKKREALYA QDPSTGCYMY YFQYLSKTYC VDATRETNRL GRLINHSKCG NCQTKLHDID GVPHLILIAS RDIAAGEELL YDYGDRSKAS IEAHPWLKH H HHHHH . | |
| Precautions | |
| KLRK1 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P26718 ) | |
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ADMEbio Team
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ADMEbio Team
