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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP1203-50 | 7 days | 50 µg | $400.00 |
Select product before adding to cart
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| RCP1203-100 | 7 days | 100 µg | $600.00 | |||
| RCP1203-1 | 7 days | 1 mg | $2,400.00 |
Product Overview | |
| Name | KRT8 Human (421-484) |
|---|---|
| Description | |
| Cytokeratin 8 (421-484 a.a) Human Recombinant | |
| Accession (Primary) | P05787 |
| Synonyms | |
| Keratin type II cytoskeletal 8, Cytokeratin-8, CK-8, Keratin-8, K8, KRT8, CYK8, KO, CK8, K2C8, CARD2. | |
| Introduction | |
| Cytokeratin 8 belongs to the type B (basic) subfamily of high molecular weight keratins and exists in combination with keratin 18. Cytokeratin 8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin polypeptides 8 and 18. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered clear solution. | |
| Formulation | |
| Cytokeratin-8 in 50mM Tris-HCl pH-7.5, 10mM L-glutathione (reduced). | |
| Stability | |
| Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles. | |
| Precautions | |
| KRT8 Human (421-484) is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P05787 ) | |
Background |
Cytokeratin 8, also known as KRT8, is a part of the type II keratin family clustered on the long arm of chromosome 12 which plays an important role in the structural integrity of epithelial cells. KRT8 pairs with keratin 18 (a type I keratin) to form heterodimers, which assemble into intermediate filaments. KRT8 takes part in retaining cellular structural integrity and also participates in signal transduction and cellular differentiation. |
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ADMEbio Team
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