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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP1229-2 | 7 days | 2 µg | $120.00 |
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| RCP1229-10 | 7 days | 10 µg | $290.00 | |||
| RCP1229-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | LBP Human, HEK |
|---|---|
| Description | |
| Lipopolysaccarid Binding Protein, Human Recombinant, HEK | |
| Accession (Primary) | P18428 |
| Synonyms | |
| Lipopolysaccharide-binding protein, LBP, Ly88. | |
| Introduction | |
| Lipopolysaccharides (LPS) are a type of glycolipids on the outer cell wall of Gram-negative bacteria. Lipopolysaccharide binding protein (aka LBP) is a plasma protein which facilitates the diffusion of bacterial LPS (endotoxin). LBP is involved in the acute-phase immunologic response to gram-negative bacterial infections. In cooperation with bactericidal permeability-increasing protein (BPI), LBP binds LPS and interacts with the CD14 receptor, most likely playing a role in regulating LPS-dependent monocyte responses. LBP belongs to a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). The LBP gene is found on chromosome 20, directly downstream of the BPI gene. LBP catalyzes the transfer of LPS monomers from LPS aggregates to HDL particles, to phospholipid bilayers, and to a binding site on soluble CD14 (sCD14). sCD14 is capable of speeding up the transfer by receiving an LPS monomer from an LPS aggregate, and then yielding it to an HDL particle, therefore acting as a soluble "shuttle" for an insoluble lipid. | |
| Source | |
| Chinese Hamster Ovarian Cells (CHO). | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Recombinant Mouse LBP was lyophilized from a protein solution (1 mg/ml) containing phosphate-buffered saline, pH 7.2. | |
| Stability | |
| Lyophilized LBP Mouse Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution LBP should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles. | |
| Biological Activity | |
| Up to 2 µg/ml LBP mediates binding of FITC-LPS (0.5 µg/ml) to CD14+CHO transfectants (2 x 10 6 /ml). | |
| Solubility | |
| It is recommended to reconstitute the lyophilized LBP in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| LBP Human, HEK is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P18428 ) | |
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ADMEbio Team
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