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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP1291-50 | 7 days | 50 µg | $400.00 |
Select product before adding to cart
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| RCP1291-100 | 7 days | 100 µg | $600.00 | |||
| RCP1291-1 | 7 days | 1 mg | $2,400.00 |
Product Overview | |
| Name | M6PR (1-60) Human |
|---|---|
| Description | |
| Mannose-6-Phosphate Receptor (1-60) Human Recombinant | |
| Accession (Primary) | P20645 |
| Synonyms | |
| CD-MPR, MPR46, MPR 46, 46-KDa Mannose 6-Phosphate Receptor, MPR-46. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Each mg was lyophilized with 1xPBS, 0.4% SDS and 4mM DTT. | |
| Stability | |
| Store lyophilized M6PRat -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. | |
| Purity | |
| Greater than 90% as determined by SDS-PAGE. | |
| Solubility | |
| It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture. | |
| Background | |
| Mannose 6-phosphate receptors are membrane proteins which take part in the intracellular transport of lysosomal enzymes. These receptors recognize and sort lysosomal hydrolases, facilitate their delivery to lysosomes via endocytic pathways. M6PR binds to mannose 6-phosphate (M6P) residues on newly synthesized lysosomal enzymes in the Golgi apparatus, directing them to lysosomes. After delivering enzymes to lysosomes, M6PRs are recycled back to the cell surface. This mechanism is critical for maintaining cellular homeostasis and efficient enzyme delivery. M6PRs may also play a role in signaling pathways, influencing cellular responses to stress and metabolic changes. Mutations or dysfunction in M6PRs can cause lysosomal storage disorders, emphasizing their importance in human health. Recombinant M6PR has significant implications in therapeutic development, mainly in understanding lysosomal storage diseases and enhancing enzyme replacement therapies. | |
| Precautions | |
| M6PR (1-60) Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P20645 ) | |
Background |
Mannose-6-Phosphate Receptor (M6PR) is a part of the P-type lectin family. P-type lectins have an important part in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The M6PR protein plays a role as a homodimer and needs divalent cations for ligand binding. Lysosomal enzymes carrying phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the ensuing receptor-ligand complex is transferred to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. |
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