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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP1366-2 | 7 days | 2 µg | $120.00 |
Select product before adding to cart
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| RCP1366-10 | 7 days | 10 µg | $290.00 | |||
| RCP1366-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | MICA Human, His |
|---|---|
| Description | |
| MHC class I chain-related gene A, Human Recombinant His Tag | |
| Accession (Primary) | Q29983 |
| Synonyms | |
| MHC class I polypeptide-related sequence B, MIC-B, MICB, PERB11.2. | |
| Introduction | |
| MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for human NKG2D type II receptor. A closely related protein, MICA, shares 85% amino acid identity with MICB. These 2 proteins are distantly related to the MHC class I proteins. MICA and MICB (MICA/B) possess three extracellular immunoglobulin-like domains, but have no capacity to bind peptide or interact with ?2-microglobulin. The genes encoding MICA/B are found within the major histocompatibility complex on human chromosome 6. The MICB locus is polymorphic with more than 15 recognized human alleles. MICA/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B are ligands for NKG2D, an activating receptor expressed on NK cells, NKT cells, ?? T cells, and CD8+ ?? T cells. Recognition of MICA/B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA/B recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. The release of soluble forms of MICA/B from tumors down-regulates NKG2D surface expression on effector cells resulting in the impairment of anti-tumor immune response. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Lyophilized from a concentrated (1mg/ml) solution containing no additives. | |
| Stability | |
| Lyophilized MICB although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MICB should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Biological Activity | |
| Measured by its ability to bind MICB antibody in ELISA. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized MICB in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| MICA Human, His is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q29983 ) | |
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ADMEbio Team
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