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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP1538-5 | 7 days | 5 µg | $120.00 |
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| RCP1538-20 | 7 days | 20 µg | $290.00 | |||
| RCP1538-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | NUDCD2 Human |
|---|---|
| Description | |
| NudC Domain Containing 2 Human Recombinant | |
| Accession (Primary) | Q8WVJ2 |
| Immunogen | |
| Anti-human NUDT1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NUDT1 amino acids 1-156 purified from E. coli. | |
| Synonyms | |
| 7,8-dihydro-8-oxoguanine triphosphatase, 8-oxo-dGTPase, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1, NUDT1, MTH1, Nudix Type Motif 1. | |
| Introduction | |
| NUDT1 is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. NUDT1 is found mostly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Moreover, NUDT1 is expressed at much higher levels in proliferating cells than in resting cells. Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations which may result in carcinogenesis or neurodegeneration. | |
| Physical Appearance | |
| Sterile filtered colorless solution. | |
| Formulation | |
| 1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide. | |
| Applications | |
| NUDT1 antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. | |
| Type | |
| Mouse Anti Human Monoclonal. | |
| Clone | |
| PAT3B3AT. | |
| Ig Subclass | |
| Mouse IgG 1 heavy chain and k light chain. | |
| Purification Method | |
| NUDT1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography. | |
| Storage Procedures | |
| For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. | |
| Stability / Shelf Life | |
| 12 months at -20°C. 1 month at 4°C. | |
| Precautions | |
| NUDCD2 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q8WVJ2 ) | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Thank you,
ADMEbio Team
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ADMEbio Team
