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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP1578-2 | 7 days | 2 µg | $350.00 |
Select product before adding to cart
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| RCP1578-5 | 7 days | 5 µg | $540.00 | |||
| RCP1578-10 | 7 days | 10 µg | $784.00 |
Product Overview | |
| Name | p53 Human |
|---|---|
| Description | |
| p53 Protein Human Recombinant | |
| Accession (Primary) | P04637 |
| Synonyms | |
| LFS1, TRP53, TP53, p53. | |
| Introduction | |
| Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered clear solution. | |
| Formulation | |
| p53 is supplied in 10mM Tris HCl, pH 8, 100mM NaCl and 50% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Type | |
| Antibody Recombinant. | |
| Precautions | |
| p53 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P04637 ) | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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ADMEbio Team
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ADMEbio Team
