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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP1622-2 | 7 days | 2 µg | $120.00 |
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| RCP1622-10 | 7 days | 10 µg | $290.00 | |||
| RCP1622-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | PEF1 Human |
|---|---|
| Description | |
| Penta-EF-Hand Domain Containing 1 Human Recombinant | |
| Accession (Primary) | Q9UBV8 |
| Synonyms | |
| Pellino E3 Ubiquitin Protein Ligase Family Member 2, Pellino-2, E3 Ubiquitin-Protein Ligase Pellino Homolog 2, Pellino (Drosophila) Homolog 2, Pellino Homolog 2 (Drosophila), Protein Pellino Homolog 2, Pellino Homolog 2, EC 6.3.2, PELI2. | |
| Introduction | |
| Pellino E3 Ubiquitin Protein Ligase Family Member 2, also known as PELI2 is an E3 ubiquitin ligase which catalyzes the covalent attachment of ubiquitin moieties onto substrate proteins. PELI2 is implicated in the TLR and IL-1 signaling pathways through interaction with the complex which contain IRAK kinases and TRAF6. PELI2 also mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. PELI2 is significant for LPS- and IL1B-induced MAP3K7-dependent, however not for MAP3K3-dependent, NF-kappa-B activation. Moreover, PELI2 can activate the MAP (mitogen activated protein) kinase pathway directing to activation of ELK1. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| PELI2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 80.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MGSSHHHHHH SSGLVPRGSH MGS MFSPGQE EHCAPNKEPV KYGELVVLGY NGALPNGDRG RRKSRFALYK RPKANGVKPS TVHVISTPQA SKAISCKGQH SISYTLSRNQ TVVVEYTHDK DTDMFQVGRS TESPIDFVVT DTISGSQNTD EAQITQSTIS RFACRIVCDR NEPYTARIFA AGFDSSKNIF LGEKAAKWKN PDGHMDGLTT NGVLVMHPRG GFTEESQPGV WREISVCGDV YTLRETRSAQ QRGKLVESET NVLQDGSLID LCGATLLWRT ADGLFHTPTQ KHIEALRQEI NAARPQCPVG LNTLAFPSIN RKEVVEEKQP WAYLSCGHVH GYHNWGHRSD TEANERECPM CRTVGPYVPL WLGCEAGFYV DAGPPTHAFT PCGHVCSEKS AKYWSQIPLP HGTHAFHAAC PFCATQLVGE QNCIKLIFQG PID. | |
| Precautions | |
| PEF1 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q9UBV8 ) | |
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