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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP1651-2 | 7 days | 2 µg | $120.00 |
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| RCP1651-10 | 7 days | 10 µg | $290.00 | |||
| RCP1651-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | PI3 Human, Sf9 |
|---|---|
| Description | |
| Peptidase Inhibitor 3 Human Recombinant, Sf9 | |
| Accession (Primary) | P19957 |
| Synonyms | |
| Phosphoinositide 3-kinase alpha p110a/p85a, PI3Ka, 2.7.1.137, Phosphatidylinositol 3-kinase, 1-phosphatidylinositol 3-kinase, PI3-kinase, PtdIns-3-kinase, Type I phosphatidylinositol kinase, Type III phosphoinositide 3-kinase. | |
| Introduction | |
| PI3Ka plays a specific role in apoptosis in human colon cancer cells. Injection of neutralizing antibodies specific to PI3Ka into adenocarcinoma cells induced apoptosis, a response that was reverted by treating cells with caspase inhibitor. It was also shown that PI3Ka mediated phosphorylation of the p85a adapter reduces the lipid kinase activity of the heterodimer and this gives hints for PI3K-dependent signaling events not requiring production of 3’-phosphorylated phosphoinositides. PI3Ka is a key regulator of the initiation of keratinocyte differentiation. A decrease in PI3Ka activity results in a loss of keratinocyte adhesion to the extracellular membrane and the initiation of early phase differentiation. | |
| Source | |
| Sf9 insect cells. | |
| Physical Appearance | |
| Sterile filtered liquid formualtion. | |
| Formulation | |
| PI3Ka solution in 25mM HEPES, pH 8.0, 25mM NaCl, 2.5mM MgCl2 and 50% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 90.0% as determined by SDS-PAGE. | |
| Specific Activity | |
| 1,000 U/mg. | |
| Unit Definition | |
| 1 unit is defined as 1 picomole phosphate transferred to PIP2 per minute. | |
| Precautions | |
| PI3 Human, Sf9 is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P19957 ) | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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ADMEbio Team
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ADMEbio Team
