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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP1814-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| RCP1814-25 | 7 days | 25 µg | $290.00 | |||
| RCP1814-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | RARRES1 Human |
|---|---|
| Description | |
| Retinoic Acid Receptor Responder 1 Human Recombinant | |
| Accession (Primary) | P49788 |
| Synonyms | |
| Chemerin, TIG2, Retinoic acid receptor responder protein 2, RAR-responsive protein TIG2, RARRES2, HP10433. | |
| Introduction | |
| RARRES2 is a secreted chemotactic protein that initiates chemotaxis through the ChemR23 G protein-coupled seven-transmembrane domain ligand. RARRES2 acts as an adipokine, and is truncated on both termini from the proprotein. RARRES2 is structurally related to the cathelicidin precursors, cystatin C and kininogens. RARRES2 promotes calcium mobilization and chemotaxis of immature dendritic cells and macrophages. RARRES2 is secreted as a precursor of little biological activity, which requires proteolytic cleavage of its COOH-terminal domain to be exchangeed into a potent and highly specific agonist of ChemR23. RARRES2 signals via its receptor, ChemR23 (CMKLR1), as a positive regulator of adipocyte differentiation and metabolic function. The Chemerin receptor acts as a coreceptor for SIV and some primary HIV-1 strains. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| The RARRES2 protein was lyophilized from 0.02% TFA. | |
| Stability | |
| Lyophilized Chemerin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Chemerin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| MELTEAQRRG LQVALEEFHK HPPVQWAFQE TSVESAAVDTP FPAGIFVRLE FKLQQTSRK RDWKKPECKV RPNGRKRKCL ACIKLGSEDK VLGRLVHCPI ETQVLREAEE HQETQCLRVQ RAGEDPHSFY FPGQFAFS. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized Chemerin in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| RARRES1 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P49788 ) | |
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