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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP1876-1 | 7 days | 1 µg | $120.00 |
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| RCP1876-5 | 7 days | 5 µg | $290.00 | |||
| RCP1876-50 | 7 days | 50 µg | $1,600.00 |
Product Overview | |
| Name | RLN2 Human, Sf9 |
|---|---|
| Description | |
| Relaxin-2 Human Recombinant, Sf9 | |
| Accession (Primary) | P04090 |
| Synonyms | |
| Relaxin 3, Prorelaxin H3, RXN3, Insl7, ZINS4, H3, Relaxin 3 (H3), Relaxin-3, RLN3. | |
| Introduction | |
| Relaxin-3 (RLN3) belongs to the relaxin family. Relaxins are endocrine and autocrine/paracrine hormones. Relaxin, which is produced by the ovary, targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. Unlike human Relaxins 1 and 2, Relaxin 3 does not seem to have a role in reproduction; however it is involved in stress response in the brain stem. RLN3 is the only known ligand for the G-protein-coupled receptor GPCR135, titled RXFP3. In addition, RLN3 binds the LGR7 (RXFP1) receptor, however with lower affinity than Relaxin-2. Even though binding of RLN3 to LGR7 increases intracellular cAMP, binding to GPCR135 suppresses cAMP accumulation, indicating coupling to Gi, Go, or Gz by this receptor. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA. | |
| Stability | |
| Lyophilized RLN3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Relaxin-3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| A chain: DVLAGLSSSC CKWGCSKSEI SSLC. B chain: RAAPYGVRLCG REFIRAVIFT CGGSRW. | |
| Biological Activity | |
| The ED 50 , as measured by cAMP accumulation in human THP-1 cells, is less than 17.5ng/ml. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized RLN3 in sterile 18M-cm H 2 O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| RLN2 Human, Sf9 is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P04090 ) | |
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