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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP2158-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
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| RCP2158-20 | 7 days | 20 µg | $290.00 | |||
| RCP2158-1 | 7 days | 1 mg | $5,760.00 |
Product Overview | |
| Name | SNF8 Human |
|---|---|
| Description | |
| SNF8, ESCRT-II Complex Subunit Human Recombinant | |
| Accession (Primary) | Q96H20 |
| Synonyms | |
| Smad nuclear-interacting protein 1, FHA domain-containing protein SNIP1, SNIP1, FLJ12553, dJ423B22.2, RP3-423B22.3. | |
| Introduction | |
| SNIP1 is smad nuclear interacting protein that contains a forkhead-associated (FHA) domain and acts as a nuclear inhibitor of CBP/p300. SNIP1 is an inhibitor of the TGF-beta signal transduction pathway and is significant in suppressing transcriptional activation dependent on the co-activators CBP and p300. Inhibition of NF-kappa B activity is a function of the N-terminal domain of SNIP1 and involves competition of SNIP1 and the NF-kappa B subunit, RelA/p65, for binding to p300, similar to the mechanism of inhibition of Smad signaling by SNIP1. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| The SNIP1 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 20% glycerol and 100mM NaCl. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 90.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MGSSHHHHHH SSGLVPRGSH M RWRLYPFKN DEVLPVMYIH RQSAYLLGRH RRIADIPIDH PSCSKQHAVF QYRLVEYTRA DGTVGRRVKP YIIDLGSGNG TFLNNKRIEP QRYYELKEKD VLKFGFSSRE YVLLHESSDT SEIDRKDDED EEEEEEVSDS. | |
| Precautions | |
| SNF8 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q96H20 ) | |
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ADMEbio Team
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ADMEbio Team
