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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP2324-5 | 7 days | 5 µg | $120.00 |
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| RCP2324-20 | 7 days | 20 µg | $290.00 | |||
| RCP2324-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | TARDBP (1-414) Human, His |
|---|---|
| Description | |
| TAR DNA Binding Protein (1-414 a.a.) Human Recombinant, His Tag | |
| Accession (Primary) | Q13148 |
| Immunogen | |
| Anti-human TARDBP mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TARDBP amino acids 1-260 purified from E. coli. | |
| Synonyms | |
| TAR DNA-binding protein 43, TDP-43, TARDBP, TDP43, ALS10. | |
| Introduction | |
| HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome which produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. TARDBP is a transcriptional repressor which binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, TARDBP regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. | |
| Physical Appearance | |
| Sterile filtered colorless solution. | |
| Formulation | |
| 1mg/ml containing PBS, pH-7.4, 10% Glycerol & 0.02% Sodium Azide. | |
| Applications | |
| TARDBP antibody has been tested by ELISA, Western blot, FACS and immunohistochemistry analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. | |
| Type | |
| Mouse Anti Human Monoclonal. | |
| Clone | |
| Pk1B8AT. | |
| Ig Subclass | |
| Mouse IgG1 heavy chain and κ light chain. | |
| Purification Method | |
| TARDBP antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. | |
| Storage Procedures | |
| For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. | |
| Stability / Shelf Life | |
| 12 months at -20°C. 1 month at 4°C. | |
| Precautions | |
| TARDBP (1-414) Human, His is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q13148 ) | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
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ADMEbio Team
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ADMEbio Team
