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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP2365-5 | 7 days | 5 µg | $120.00 |
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| RCP2365-20 | 7 days | 20 µg | $290.00 | |||
| RCP2365-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | TGIF2LY Human |
|---|---|
| Description | |
| TGFB-Induced Factor Homeobox 2-Like Y-Linked Human Recombinant | |
| Accession (Primary) | Q8IUE0 |
| Synonyms | |
| Protein gamma-glutamyltransferase 2, EC 2.3.2.13, Tissue transglutaminase, TGase C, TGC, TG(C), Transglutaminase-2, TGase-H, TG2, TGM2. | |
| Introduction | |
| Celiac disease is an enteropathy that is characterized by intestinal lesions of variable severity. Tissue-type transglutaminase (tTG) is believed to be the predominant autoantigen for celiac disease and the corresponding autoantibodies show higher sensitivity and specificity than anti-gliadin antibodies. Highly pure recombinant human tTG is now available to replace the traditionally used tTG fraction from guinea pig. Tissue-type transglutaminase antigens have been specifically modified for improved handling: exchange of an active site amino acid eliminates the protein cross-linking activity of the enzyme, while maintaining the native three-dimensional structure and the enzyme's secondary GTPase activity. This engineering assures reproducible properties of the antigen preparations through the absence of variable and ill-defined covalent aggregates of tTG antigen and host cell proteins. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered clear solution. | |
| Formulation | |
| TGM2 is supplied in 16mM HEPES buffer pH-8.0, 400mM NaCl, and 20% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 95% as determined by SDS-PAGE. | |
| Precautions | |
| TGIF2LY Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q8IUE0 ) | |
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ADMEbio Team
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ADMEbio Team
