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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP2375-100 | 7 days | 100 µg | $600.00 |
Select product before adding to cart
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| RCP2375-500 | 7 days | 500 µg | $1,200.00 | |||
| RCP2375-1 | 7 days | 1 mg | $1,440.00 |
Product Overview | |
| Name | Thyroglobulin Human |
|---|---|
| Description | |
| Thyroglobulin Human Recombinant | |
| Accession (Primary) | P01266 |
| Synonyms | |
| Thyroglobulin, TGN, AITD3, TG. | |
| Introduction | |
| Thyroglobulin (TG) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. TG is a large globular dimeric glycoprotein with a total molecular weight of 660 kDa, which occupies a key precursor role in the biosynthesis of the thyroid hormones. Approximately 75% of the total protein content of the thyroid follicle consists of TG. The thyroid gland uses the Thyroglobulin in order to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is produced by the thyroid epithelial cells (thyrocytes) which form spherical follicles. Thyroglobulin is subsequently secreted and stored in the follicular lumen. Patients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against Thyroglobulin. Tg-specific antibodies help in the diagnosis of the above diseases, however they also may be present in apparently healthy euthyroid individuals. Blood Thyroglobulin levels can be used as a tumor marker for certain kinds of thyroid cancer, and the may also be elevated in cases of Graves' disease. | |
| Source | |
| Human thyroid glands. | |
| Physical Appearance | |
| Sterile Filtered Off-White lyophilized (freeze-dried) powder. | |
| Formulation | |
| Lyophilized from 0.02M NH4HCO3. May contain traces of buffer salts. | |
| Stability | |
| Human Thyroglobulin although stable at room temperature for 3 weeks, should be stored between 2-8°C. | |
| Purity | |
| Greater than 98.0%. | |
| Solubility | |
| Use phosphate buffer, pH>7.0 containing 0.15M NaCl is recommended. | |
| Human Virus Test | |
| Starting material tested and certified negative for HIV I & II antibodies, Hepatitis B surface antigen, Hepatitis C antibodies, Syphilis and HIV-1/HBV/HCV NAT. | |
| Precautions | |
| Thyroglobulin Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P01266 ) | |
Background |
Thyroglobulin, a glycoprotein primarily produced in the thyroid gland, stands at the center of thyroid hormone synthesis. Comprising a series of tyrosine residues, thyroglobulin serves as the scaffold upon which thyroid hormones are assembled. Beyond its pivotal role in thyroid physiology, thyroglobulin has garnered significant attention in the realm of thyroid disease diagnostics, offering valuable insights into thyroid function and disorders. This research delves into the intricacies of thyroglobulin human recombinant protein, exploring its biochemical properties, physiological significance, and its crucial applications in both clinical and research settings. Structural Complexity of Thyroglobulin: Thyroglobulin is a large, dimeric protein boasting an intricate structure composed of multiple domains. Within its structure lie tyrosine residues crucial for iodine incorporation, a process fundamental for thyroid hormone synthesis. Its size and complexity reflect the sophistication of thyroid hormone production, as thyroglobulin acts as a reservoir for thyroid hormones within the thyroid follicles. Physiological Significance in Thyroid Function: Thyroglobulin plays a central role in the synthesis of triiodothyronine (T3) and thyroxine (T4), the thyroid hormones essential for regulating metabolism and overall body homeostasis. During thyroid hormone synthesis, thyroglobulin is secreted into the follicular lumen, where it undergoes iodination and subsequent proteolysis, releasing T3 and T4. This process highlights the indispensable nature of thyroglobulin in thyroid hormone production, making it a key biomolecule in thyroid physiology. |
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