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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP2378-2 | 7 days | 2 µg | $120.00 |
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| RCP2378-10 | 7 days | 10 µg | $290.00 | |||
| RCP2378-1 | 7 days | 1 mg | $8,320.00 |
Product Overview | |
| Name | TICAM2 Human |
|---|---|
| Description | |
| Toll-Like Receptor Adaptor Molecule 2 Human Recombinant | |
| Accession (Primary) | Q86XR7 |
| Synonyms | |
| Tyrosine kinase with immunoglobulin-like and EGF-like domains 1, JTK14, TIE, TIE1. | |
| Introduction | |
| TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Whereas two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], so far no ligand was found for TIE-1. | |
| Source | |
| Insect Cells. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| TIE-1 Fc Chimera was lyophilized from a concentrated (1mg/ml) sterile solution containing 20mM Tris, 0.5M NaCl, 10% Sucrose. | |
| Stability | |
| Lyophilized sTIE-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TIE-1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 90.0% as determined by: (A) Analysis by RP-HPLC. (B) Analysis by SDS-PAGE. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized TIE-1 Fc Chimera in sterile water not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| TICAM2 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q86XR7 ) | |
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ADMEbio Team
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