Hello, Sign in
My Account
My Account
New customer? Start here
| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP2438-5 | 7 days | 5 µg | $120.00 |
Select product before adding to cart
|
||
| RCP2438-20 | 7 days | 20 µg | $290.00 | |||
| RCP2438-1 | 7 days | 1 mg | $5,760.00 |
Product Overview | |
| Name | TRIM21 Human |
|---|---|
| Description | |
| Tripartite Motif Containing 21 (RO52) Human Recombinant | |
| Accession (Primary) | P19474 |
| Synonyms | |
| 52 kDa Ro protein, Sjoegren syndrome type A antigen, SS-A, Ro(SS-A), 52 kDa ribonucleoprotein autoantigen Ro/SS-A, Tripartite motif-containing protein 21, RING finger protein 81, TRIM21, RNF81, RO52, SSA1, SSA, RO-52. | |
| Introduction | |
| TRIM21 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The 52 kDa Ro protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. Ro/SSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Ribonucleoprotein particle is composed of a single polypeptide and one of four small RNA molecules. The RoSSA is present in all mammalian cells studied but has no known function. At least 2 isoforms are present in nucleated and red blood cells, and tissue specific differences in Ro/SSA proteins were identified. | |
| Source | |
| Sf9 insect cells. | |
| Physical Appearance | |
| Sterile Filtered clear solution. | |
| Formulation | |
| TRIM21 solution is supplied in 20mM HEPES pH-7.6, 0.01mM EDTA and 0.02% SDS. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 80% as determined by SDS-PAGE. | |
| Immunological functions | |
| 1. Binds IgG type human auto antibodies. 2. Functional Streptavidin based ELISA test (analysis of positive/negative samples.) | |
| Precautions | |
| TRIM21 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P19474 ) | |
References |
1. Title :graft-versus-host disease Recovery of B-cell homeostasis. Publication :doi:10.1182/blood-2010-10-307819 Prepublished online November 19, 2010;2011 117: 2275-2283. Link : TRIM21 prospec publication |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Thank you,
ADMEbio Team
ADMEbio welcomes feedback from our customers.
Thank you,
ADMEbio Team
