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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP2476-10 | 7 days | 10 µg | $120.00 |
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| RCP2476-50 | 7 days | 50 µg | $290.00 | |||
| RCP2476-1 | 7 days | 1 mg | $2,880.00 |
Product Overview | |
| Name | TXN1 Human |
|---|---|
| Description | |
| Thioredoxin Human Recombinant | |
| Accession (Primary) | P10599 |
| Synonyms | |
| Thioredoxin, ATL-derived factor, ADF, Surface-associated sulphydryl protein, SASP, TXN, TRDX, TRX, TRX1, MGC61975, DKFZp686B1993. | |
| Introduction | |
| Thioredoxins are small disulphide-containing redox proteins (within the conserved Cys-Gly-Pro-Cys active site) that have been found in all the kingdoms of living organisms. Thioredoxin contains a single disulfide active site and serves as a general protein disulphide oxidoreductase. Thioredoxins are involved in the first unique step in DNA synthesis. It interacts with a broad range of proteins by a redox mechanism based on reversible oxidation of two cysteine thiol groups to a disulphide, accompanied by the transfer of two electrons and two protons. The net result is the covalent interconversion of a disulphide and a dithiol. It has been suggested that thioredoxin may catalyze the formation of correct disulfides during protein folding because of its ability to act as an efficient oxidoreductant. Trx also provides control over a number of transcription factors affecting cell proliferation and death through a mechanism referred to as redox regulation. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile filtered colorless solution. | |
| Formulation | |
| TXN1 solution containing 1x PBS pH 7.4. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 95.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MGSSHHHHHH SSGLVPRGSH MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT INELV. | |
| Biological Activity | |
| Specific activity is 7-10 A650/min/mg, obtained by measuring the increase of insulin precipitation in absorbance at 650 nm resulting from the reduction of insulin. | |
| Precautions | |
| TXN1 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P10599 ) | |
References |
Title :Exogenous thioredoxin prevents ethanol-induced oxidative damage and apoptosis in mouse liver. Publication :Article first published online: 4 FEB 2009 DOI:10.1002/hep.22837 Copyright © 2009 American Association for the Study of Liver Diseases. Link : TXN1 prospec publication |
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