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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP2490-5 | 7 days | 5 µg | $120.00 |
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| RCP2490-20 | 7 days | 20 µg | $290.00 | |||
| RCP2490-1 | 7 days | 1 mg | $4,480.00 |
Product Overview | |
| Name | Ubiquitin G76A Human |
|---|---|
| Description | |
| Ubiquitin G76A Human Recombinant | |
| Accession (Primary) | P62988 |
| Synonyms | |
| Ubiquitin, Ribosomal Protein S27a, CEP80, UBA80, UBCEP1, UBCEP80, HUBCEP80, RPS27A, Ubiquitin K48R. | |
| Introduction | |
| Ubiquitin is a highly conserved 76 amino acid protein expressed in all eukariotes. Ub is found either in free form or conjugated to proteins as monomer or as chain of ubiquitin molecules. The most well characterized consequence of polyubiquitination is substrate degradation, while mono-ubiquitinated proteins are not degraded. Ubiquitin attachment to protein substrate is a complex process involving a ubiquitin activating enzyme (E1), a ubiquitin conjugating enzyme (E2) and a ubiquitin protein ligase (E3). The first ubiquitin moiety is transferred to the e-NH2 group of a Lys residue of the protein substrate to generate an isopeptide bond. In successive reactions, a poly ubiquitin chain is synthesized by processive transfer of additional activated moieties to Lys48 of the previously conjugated ubiquitin molecule. Ubiquitin K48R prevents the formation of poly ubiquitin chains via Lys48 linkages with mono ubiquitin molecules, avoiding the degradation of protein substrates. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered clear solution. | |
| Formulation | |
| Diluted in PBS plus 5% glycerol. | |
| Stability | |
| Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95% as determined by SDS-PAGE. | |
| Precautions | |
| Ubiquitin G76A Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P62988 ) | |
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ADMEbio Team
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