Hello, Sign in
My Account
My Account
New customer? Start here
| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP2503-50 | 7 days | 50 µg | $400.00 |
Select product before adding to cart
|
||
| RCP2503-100 | 7 days | 100 µg | $600.00 | |||
| RCP2503-1 | 7 days | 1 mg | $2,400.00 |
Product Overview | |
| Name | UCP3 Human |
|---|---|
| Description | |
| Uncoupling protein 3 Human Recombinant | |
| Accession (Primary) | P55916 |
| Synonyms | |
| Ubiquitin-fold modifier-conjugating enzyme 1, Ufm1-conjugating enzyme 1, UFC1, CGI-126, HSPC155. | |
| Introduction | |
| UFC1 is a member of the ubiquitin-conjugating enzyme family. UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1. UFM1 is activated by UBA5 (a novel E1-like enzyme) by forming a high-energy thioester bond. Activated UFM1 is subsequently transferred to its cognate E2-like enzyme, UFC1, in a similar thioester linkage. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered clear solution. | |
| Formulation | |
| UFC1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT. | |
| Stability | |
| UFC1 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles. | |
| Purity | |
| Greater than 90% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MGSSHHHHHH SSGLVPRGSH MADEATRRVV SEIPVLKTNA GPRDRELWVQ RLKEEYQSLI RYVENNKNAD NDWFRLESNK EGTRWFGKCW YIHDLLKYEF DIEFDIPITY PTTAPEIAVP ELDGKTAKMY RGGKICLTDH FKPLWARNVP KFGLAHLMAL GLGPWLAVEI PDLIQKGVIQ HKEKCNQ. | |
| Precautions | |
| UCP3 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( P55916 ) | |
Background |
Uncoupling protein 3 (UCP3) is a mitochondrial protein which takes part in energy metabolism and thermoregulation. UCP3 Function Proton Uncoupling - UCP3 helps dissipate the proton gradient across the inner mitochondrial membrane. This uncoupling leads to the production of heat instead of ATP, a necessary process for thermogenesis. Energy Regulation - UCP3 takes part in the regulation of energy expenditure and can influence metabolic efficiency. UCP3 Location UCP3 is predominantly expressed in skeletal muscle and brown adipose tissue, where its activity is critical for energy metabolism. UCP3 Role in Metabolism according to some studies, UCP3 may improve insulin sensitivity and help manage body weight. In addition, UCP3 participates in the metabolism of fatty acids and may help reduce the accumulation of reactive oxygen species (ROS) by decreasing oxidative stress. UCP3 Regulation UCP3 expression can raise in response to physical activity, emphasising its role in adapting to varius energy demands during exercise. Changes in UCP3 levels have been associated with diabetes, obesity and other metabolic disorders. Clinical Relevance UCP3 is being investigated as a potential target for obesity and metabolic disease treatments because of its role in energy balance UCP3 is a central player in energy metabolism and thermogenesis, with implications for metabolic health and the body's response to exercise and diet. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Thank you,
ADMEbio Team
ADMEbio welcomes feedback from our customers.
Thank you,
ADMEbio Team
