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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| RCP2509-5 | 7 days | 5 µg | $120.00 |
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| RCP2509-20 | 7 days | 20 µg | $290.00 | |||
| RCP2509-1 | 7 days | 1 mg | $4,320.00 |
Product Overview | |
| Name | ULBP2 Human |
|---|---|
| Description | |
| UL16 Binding Protein 2 Human Recombinant | |
| Accession (Primary) | Q9BZM5 |
| Synonyms | |
| ULBP2, ALCAN-alpha, N2DL2, NKG2DL2, RAET1H, UL16 Binding Protein 2, Retinoic Acid Early Transcript 1H, UL16-Binding Protein 2, ALCAN-Alpha, NKG2D Ligand 2, N2DL-2. | |
| Introduction | |
| ULBP2 is a member of the MHC class I family. ULBP2 is ligand for the NKG2D receptor, composed with at least ULBP1 and ULBP3. ULBPs promote multiple signaling pathways in primary NK cells, triggering the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D encourages calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, ULBP2 cooperates with soluble CMV glycoprotein UL16. This cooperation is blocked with the NKG2D receptor, providing a mechanism in which CMV infected cells can escape the immune system. Additionally, UL16 causes ULBP2 to be held in the ER and cis-Golgi apparatus so that it does not reach the cell surface. | |
| Source | |
| Sf9, Baculovirus cells. | |
| Physical Appearance | |
| Sterile Filtered colorless solution. | |
| Formulation | |
| ULBP2 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol. | |
| Stability | |
| Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | |
| Purity | |
| Greater than 90% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| ADP GRADPHS LCYDITVIPK FRPGPRWCAV QGQVDEKTFL HYDCGNKTVT PVSPLGKKLN VTTAWKAQNP VLREVVDILT EQLRDIQLEN YTPKEPLTLQ ARMSCEQKAE GHSSGSWQFS FDGQIFLLFD SEKRMWTTVH PGARKMKEKW ENDKVVAMSF HYFSMGDCIG WLEDFLMGMD STLEPSAGAP LAMS HHHHHH . | |
| Precautions | |
| ULBP2 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( Q9BZM5 ) | |
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Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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ADMEbio Team
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ADMEbio Team
