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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| CYK0599-100 | 7 days | 100 µg | $400.00 |
Select product before adding to cart
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| CYK0599-0.5 | 7 days | 0.5 mg | $1,600.00 | |||
| CYK0599-1 | 7 days | 1 mg | $2,240.00 |
Product Overview | |
| Name | TNFSF14 Human |
|---|---|
| Description | |
| LIGHT Human Recombinant | |
| Accession (Primary) | O43557 |
| Synonyms | |
| Tumor necrosis factor ligand superfamily member 14, CD258, Tnfsf14, Light. | |
| Introduction | |
| TNFRSF14, a member of the TNF receptor superfamily, is a type I transmembrane protein. TNFRSF14 is expressed in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. TNFRSF14 operates as a co-stimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. Additionally, TNFRSF14 encourages the proliferation of T cells, and triggers apoptosis of various tumor cells. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered White lyophilized (freeze-dried) powder. | |
| Formulation | |
| TNFSF14 protein was lyophilized from a 0.2 µm filtered concentrated solution in PBS pH7.4. | |
| Stability | |
| Lyophilized TNFSF14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TNFSF14 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 96.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | |
| Amino acid sequence | |
| DGGKGSWEKL IQDQRSHQAN PAAHLTGANA SLIGIGGPLL WETRLGLAFL RGLTYHDGAL VTMEPGYYYV YSKVQLSGVG CPQGLANGLP ITHGLYKRTS RYPKELELLV SRRSPCGRAN SSRVWWDSSF LGGVVHLEAG EEVVVRVPGN RLVRPRDGTR SYFGAFMV. | |
| Biological Activity | |
| The ED 50 as determined by a cytotoxicity assay using human HT-29 cells is less than 2 µg/ml, corresponding to a specific activity of > 500 IU/mg in the presence of murine anti-polyHistidine monoclonal antibody and rHuIFN- g . | |
| Solubility | |
| It is recommended to reconstitute the lyophilized TNFSF14 in sterile 100mM HAc not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| TNFSF14 Human is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( O43557 ) | |
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ADMEbio Team
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ADMEbio Team
