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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| VAG0322-2 | 7 days | 2 µg | $120.00 |
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| VAG0322-10 | 7 days | 10 µg | $290.00 | |||
| VAG0322-100 | 7 days | 100 µg | $1,600.00 |
Product Overview | |
| Name | HIV-1 NEF Biotin |
|---|---|
| Description | |
| HIV-1 nef Recombinant Biotin Labeled | |
| Accession (Primary) | CAA41585 |
| Introduction | |
| HIV-1 Nef is a 27kDa protein highly produced after a very short time after virus infection. HIV-1 Nef is an essential factor for efficient viral replication and phatogenesis. HIV-1 Nef facilitates virus replication and improves virions infectivity. HIV-1 Nef exerts pleiotropic effect. HIV-1 Nef down-modulates surface MHC-I molecules, decreases cell surface CD4 antigen by interacting with the Src family kinase LCK thereby inducing LCK-CD4 dissociation and by increasing clathrindependent endocytosis of this antigen to target it to lysosomial degradation. HIV-1 Nef guards the infected cell from apoptosis in order to keep it alive until the next virus generation is ready to strike. HIV-1 Nef protein bypasses host Tcell signaling by inducing a transcriptional program nearly identical to that of anti-CD3 cell activation. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered and lyophilized, though might appear as a solution as a result of the glycerol content. | |
| Formulation | |
| Lyophilized with 1% glycerol. | |
| Stability | |
| Lyophilized HIV-1 nef although stable at room temperature for 1 week, should be stored desiccated below -18°C. Upon reconstitution HIV-1 nef should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 90.0% as determined by HPLC analysis and SDS-PAGE. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized HIV-1 nef in sterile 18M-cm H 2 O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Precautions | |
| HIV-1 NEF Biotin is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( CAA41585 ) | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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ADMEbio Team
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ADMEbio Team
