Hello, Sign in
My Account
My Account
New customer? Start here
| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| VAG0326-100 | 7 days | 100 µg | $330.00 |
Select product before adding to cart
|
||
| VAG0326-500 | 7 days | 500 µg | $1,320.00 | |||
| VAG0326-1000 | 7 days | 1000 µg | $2,160.00 |
Product Overview | |
| Name | HIV-1 p24 gag |
|---|---|
| Description | |
| HIV-1 p24 gag Recombinant | |
| Introduction | |
| Human immunodeficiency virus (HIV) is a retrovirus that can lead to a condition in which the immune system begins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophage sand dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells; secondly, increased rates of apoptosis in infected cells; and thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus, part of the Retroviridae family. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genome is converted to double-stranded DNA by a virally encoded reverse transcriptase that is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integrase so that the genome can be transcribed. Once the virus has infected the cell, two pathways are possible: either the virus becomes latent and the infected cell continues to function, or the virus becomes active and replicates, and a large number of virus particles are liberated that can then infect other cells. The p24 protein is detected in patient blood as early as 2 weeks after HIV infection, further reducing the window period necessary to accurately detect the HIV status of the patient. | |
| Physical Appearance | |
| 2 vials of sterile filtered clear colorless solution. | |
| Formulation | |
| *HIV-1 p24 coating antibody contains PBS, pH 7.4. * HIV-1 p24 conjugating antibody contains PBS, pH 7.4. | |
| Stability | |
| HIV-1 p24 antibody although stable at 4°C for 1 week, should be stored below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 95%. | |
| Applications | |
| Lateral flow immunoassay. | |
| Type | |
| Mouse Anti Human Monoclonal. | |
| Purification Method | |
| Purified by protein A affinity column. | |
| Precautions | |
| HIV-1 p24 gag is for research use only and not for use in diagnostic or therapeutic procedures. | |
References |
Title: Polyfunctional CD4+ and CD8+ T Cell Responses to Tuberculosis Antigens in HIV-1–Infected Patients before and after Anti-Retroviral Treatment Publication: The Journal of Immunology 184.11 (2010): 6537-6544. Link: HIV-1 p24 gag prospec publication |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Thank you,
ADMEbio Team
ADMEbio welcomes feedback from our customers.
Thank you,
ADMEbio Team
