Hello, Sign in
My Account
My Account
New customer? Start here
| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| VAG0336-2 | 7 days | 2 µg | $120.00 |
Select product before adding to cart
|
||
| VAG0336-10 | 7 days | 10 µg | $290.00 | |||
| VAG0336-100 | 7 days | 100 µg | $1,920.00 |
Product Overview | |
| Name | HIV-1 TAT Clade-A |
|---|---|
| Description | |
| HIV-1 TAT Clade-A Recombinant | |
| Accession (Primary) | 37693985 |
| Introduction | |
| Human immunodeficiency virus type-1 (HIV-1) regulatory Tat protein plays an essential role in viral replication (Jones KA, 1994) and infectivity (Arya SK, 1985; Fisher AG, 1986). In addition, during acute infection, Tat is released extracellularly by infected cells (Chang HC, 1997; Ensoli B, 1990) and is taken up by neighboring cells where it transactivates viral replication (Ensoli B, 1993) and increases virus infectivity. HIV-1 Tat activates transcription of HIV-1 viral genes by inducing phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Tat can also disturb cellular metabolism by inhibiting proliferation of antigen-specific T lymphocytes and by inducing cellular apoptosis. Tat-induced apoptosis of T-cells is attributed, in part, to the distortion of microtubules polymerization. LIS1 is a microtubule-associated protein that facilitates microtubule polymerization. | |
| Source | |
| Escherichia Coli. | |
| Physical Appearance | |
| Sterile Filtered and lyophilized, though might appear as a solution as a result of the glycerol content. | |
| Formulation | |
| Lyophilized with 0.1% glycerol. | |
| Stability | |
| Lyophilized HIV-1 TAT although stable at room temperature for 1 week, should be stored desiccated below -18°C. Upon reconstitution HIV-1 TAT should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. | |
| Purity | |
| Greater than 90.0% as determined by SDS-PAGE. | |
| Amino acid sequence | |
| MEPVDPRLEP WKHPGSQPKT ACTNCYCKKC CFHCQVCFIT KALGISYGRK KRRQRRRPPQ GSQTHQVSLS KQPTSQSRGD PTGPKE. | |
| Solubility | |
| It is recommended to reconstitute the lyophilized HIV-1 TAT in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. | |
| Specificity | |
| Immunoreactive with all sera of HIV-1 infected individuals. | |
| Precautions | |
| HIV-1 TAT Clade-A is for research use only and not for use in diagnostic or therapeutic procedures. | |
Target Information: ( 37693985 ) | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Thank you,
ADMEbio Team
ADMEbio welcomes feedback from our customers.
Thank you,
ADMEbio Team
