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| Catalog # | Availability | Size | Quantity | Unit Price | Save For Later Wish List | |
|---|---|---|---|---|---|---|
| VAG0429-100 | 7 days | 100 µg | $330.00 |
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| VAG0429-500 | 7 days | 500 µg | $1,320.00 | |||
| VAG0429-1000 | 7 days | 1000 µg | $1,760.00 |
Product Overview | |
| Name | SARS Core (340-390) |
|---|---|
| Description | |
| SARS-Associated Coronavirus Nucleocapsid Core Recombinant, (340-390 a.a) | |
| Immunogen | |
| The native monoclonal antibody was generated by sequencing peripheral blood lymphocytes of a patient exposed to the SARS-CoV | |
| Introduction | |
| SARS Coronavirus is an enveloped virus containing three outer structural proteins, namely the membrane (M), envelope (E), and spike (S) proteins. Spike (S)-glycoprotein of the virus interacts with a cellular receptor and mediates membrane fusion to allow viral entry into susceptible target cells. Accordingly, S-protein plays an important role in virus infection cycle and is the primary target of neutralizing antibodies.It has recently been shown that SARS is caused by a human coronavirus. Human coronaviruses are the major cause of upper respiratory tract illness in humans, such as the common cold. Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). The first step in coronavirus infection is binding of the viral spike protein, a 139-kDa protein, to certain receptors on host cells. The spike protein is the main surface antigen of the coronavirus. The most prominent protein in the culture supernatants infected with SARS virus is a 46 kDa nucleocapsid protein. This suggests that the nucleocapsid protein is a major immunogen that may be useful for early diagnostics. | |
| Source | |
| HEK293 Cells. | |
| Physical Appearance | |
| Sterile Filtered liquid formulation. | |
| Formulation | |
| 1mg/ml in PBS and 0.02% Proclin 300. | |
| Stability | |
| Store at 4°C, stable for 2 weeks. For long-term storage, store at -20°C. | |
| Applications | |
| ELISA CoV-2 IgG S1 antibody binds to both SARS-CoV and SARS-CoV-2 (COVID-19) with high affinity at amino acids 318-510 in the S1 domain of the Spike protein. | |
| Type | |
| Mouse antibody Monoclonal. | |
| Purification Method | |
| Protein A affinity purified. | |
| Specificity | |
| The ELISA Plate was coated with the target proteins at 5 µg/ml. Primary antibodies were titrated on a 3-fold serial dilution starting at 125 ng/ml, CoV-2 IgG S1 antibody recognises SARS-CoV-2 spike protein subunit 1 (aa 1-674), or 41.6 ng/ml CoV-2 IgG S1 antibody recognised spike protein from SARS-CoV (subunit 1, aa 1-666) and SARS-CoV-2 (subunit 1, aa 1-674). Secondary antibody anti-human IgG conjugated to HRP used in the assay, at 1:4000 concentration. | |
| Precautions | |
| SARS Core (340-390) is for research use only and not for use in diagnostic or therapeutic procedures. | |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from ADMEbio to advance their research.
Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Thank you,
ADMEbio Team
ADMEbio welcomes feedback from our customers.
Thank you,
ADMEbio Team
